The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats
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چکیده
منابع مشابه
The preventive effects of dexmedetomidine against intestinal ischemia-reperfusion injury in Wistar rats
Objective(s): Intestinal ischemia-reperfusion is a major problem, which may lead to multiorgan failure and death. The aim of this study was to evaluate the protective effects of dexmedetomidine on cell proliferation, antioxidant system, cell death, and structural integrity in intestinal injury induced by ischemia-reperfusion in rats. Materials and Methods: Animals were randomized into three gro...
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Hepatic ischemia-reperfusion (I/R) is a common phenomenon during liver surgery, transplantation, infection and trauma which results in damage and necrosis of the hepatic tissue through different pathways. Mechanisms involved in I/R damage are very intricate and cover several aspects. Several factors are involved in I/R-induced damages; briefly, decrease in sinusoidal perfusion and ATP generatio...
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BACKGROUND/AIMS Mesenteric ischemia/reperfusion injury induces a systemic response and releases harmful substances that may affect distant organs such as the lung, liver and kidney. We designed this study to determine if curcumin has protective effects against mesenteric ischemia/reperfusion injury and mesenteric ischemia/reperfusion-induced intestinal and distant organ injury. METHODS Forty ...
متن کاملProtective effects of dexmedetomidine and remote ischemic preconditioning on renal ischemia reperfusion injury in rats.
BACKGROUND The aim of this study was to evaluate the effects of remote ischemic preconditioning (RIPC) and dexmedetomidine as pharmacological conditioning in a rat renal ischemia/reperfusion (IR) injury model. METHODS Total of 28 male Wistar Albino rats weighing 250 to 300 g were divided into 4 equal groups. Group I (Sham; n=7): Laparotomy and renal pedicle dissection were performed, and the ...
متن کاملThe protective effect of glycyrrhizin on hepatic ischemia-reperfusion injury in rats and possible related signal pathway
Objective(s): To investigate the protective effect of glycyrrhizin (GL) on hepatic ischemia-reperfusion injury (HIRI).Materials and Methods: Forty SD rats were randomly divided into sham group, HIRI group, GL 100 mg/kg group, and GL 200 mg/kg group. The pathological alterations of liver tissue in each group were observed. The levels of a...
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ژورنال
عنوان ژورنال: International Journal of Surgery
سال: 2013
ISSN: 1743-9191
DOI: 10.1016/j.ijsu.2012.12.003